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Yi-juang Chern Professor
神經訊息傳導研究室
image Yijuang Chern   Professor( Adjunct )
bmychern@ibms.sinica.edu.tw
Tel : 02-27899028
Fax : 02-27829143


>> Link:http://www.ibms.sinica.edu.tw/Ehtml/pi_e/ychern.html
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Considerable evidence has demonstrated that adenosine modulates a wide variety of cellular functions, including neuronal secretion and locomotor activity, in various tissues. To date, four adenosine receptors ( A1, A2A, A2B and A3 ) have been identified.We have successfully cloned and characterized the cDNA and the gene of rat A2A adenosine receptor (A2A-R). Activation of A2A-R results in elevation of intercellular cAMP contents.The principal objective of this research group is to understand the physiological functions and the regulation of A2A-R. Two different aproaches are used to accomplish this goal: to further characterize the gene structure and regulation of A2A-R under physiological conditions, and to examine the regulation of A2A-R mediated cAMP response during prolonged activation of A2A-R. Results of our study will provide fundamental insights into the action of adenosine, and might lead to greater therapeutic application of adenosine.
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image Chiang M-C, Lee Y-C, Huang C-L and Chern Y. (2005) CREB contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine resides. J. Biol. Chem. 280: 14331–14340.
image Chou S-Y, Lee Y-C, Chen H-M, Chiang M-C, Lai H-L, Chang H-H, Wu-Y-C, Sun C-N, Chien C-L, Lin Y-S, Wang S-C, Tung Y-Y, Chang C and Chern Y. (2005) CGS21680 attenuates symptoms of Huntington’s disease in a transgenic mouse model. J. Neurochem. 93: 310-320.
image Lee Y-C, Chang C-W, Su C-W, Lin T-N, Sun SH, Lai H-L and Chern Y. (1999) The 5' Untranslated Regions of Rat A2A Adenosine Receptor Gene Function as Negative Translational Regulators. J. Neurochem. 73: 1790-1798.
image Lai H-L, Lin T-H, Kao Y-Y, Lin W-J, Hwang M-J and Chern Y. (1999) The Nterminal domain of Type VI Adenylyl Cyclase Mediates Its Inhibition by Protein Kinase C. Mol. Pharm. 56: 644-650
image Liu F-C, Wu G-C, Hsieh S-T, Lai H-L, Wang H-F, Wang T-W and Chern Y. (1998) Expression of Type VI Adenylyl Cyclase in the Central Nervous System: Implication for a potential regulator of multiple signals in different neurotransmitter systems. FEBS Lett.436:92-98.
image Chang YH, Conti M, Lee Y-C, Lai H-L, ChingY-H and Chern Y. (1997) Activation of Phosphodiesterase IV During Desensitization of the A2A-adenosine Receptor-mediated cAMP Response in Rat Pheochromocytoma (PC12) Cells. J. Neurochem. 69: 1300-1309.
image Lai H-L, Yang T-H, Messing RO, Ching Y-H, Lin S-C and Chern Y. (1997) Protein kinase C Inhibits Adenylyl Cyclase Type VI Activity During Desensitization of the A2A-Adenosine Receptor-Mediated cAMP Response. J. Biol.Chem. 272: 4970-4977.
image Chu Y-Y, Tu K-H, Lee Y-C, Kuo Z-J, Lai H-L and Chern Y. (1996) Characterization of Rat A2A Adenosine Receptor Gene. DNA and Cell Biology, 15: 329-337.
image Chern, Y, Chiou J-Y, Lai H-L and Tsai M-H. (1995) Regulation of Adenylyl Cyclase Type VI Activity During Desensitization of the A2A-Adenosine Receptor-Mediated cAMP Response:A Role for Protein Phosphatase 2A. Mol.Pharmacology, 48:1-8.
   
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